Abbas R , Hartmann O, Asiss DT, Abbas R, Kagan J, Kim HT, Oren M, Diefenbacher, M, Orian A, Larisch S. (2024) ARTS and small-molecule ARTS mimetics upregulate p53 levels by promoting the degradation of XIAP (Apoptosis, accepted for publication).
Novak R, Abu Ahmed1Y, Timaner M, Bitman-Lotan L, Oknin-Vaisman A, Nikomarov D, Diefenbacher M, Shaked Y, Orian A. (2022) RNF4-RGMb axis is required for osteogenic differentiation and cancer cell survival. Cell Death & Disease 13:820.
Abu Ahmad Y., Oknin-Vaisman A., Lotan-Bitman E. and Orian A. (2021) From the evasion of degradation to ubiquitin-dependent protein stabilization Cells, 10 :2374.
Erez, N., Israitel L., Bitman-Lotan E., Wong, W. H., Raz G., Danial S., Flint Brodsly N., Belova, E., Maksimenko, O., Georgiev P., Druley, T., Mohan R., Orian A. (2021) A Non-stop identity complex (NIC) supervises enterocyte identity and protects from pre-mature aging. e-Life 10:e62312.
Bitman-Lotan E, Orian A. (2021) Nuclear organization and regulation of the differentiated state. Cellular and Molecular Life Sciences 0.1007/s00018-020-03731-4.
Hartmann, O., Reissland M., Maier C. R. , Fischer, T., Prieto-Garcia, C., Baluapuri, A., Schwarz, J., Schmitz, W., Garrido-Rodríguez, M., Pahor, N., Davies, C. C., Orian, A., Wolf, E., Schulze, A., Calzado, M. A., Rosenfeldt, M. T., Diefenbacher M. (2021) Implementation of CRISPR/Cas9 genome editing to generate murine lung cancer models that depict the mutational landscape of the human disease. Frontiers in Cell and Developmental Biology 9:641618.
Avitan-Hersh E., Feng Y., Oknin-Vaisman A., Abu-Ahmed Y., Zhang T., Zohar Y., Lazar I., Khalil S., Feiler Y., Lee S J., Kluger H., Kahana H., Brown K., Ruppin E., Ronai Z., Orian A. (2020) Regulation of eIF2a by RNF4 underlies melanoma development and therapy resistance. J. Investigative Dermatology 29: S0022-202; 31404-3114.
Cammarata-Mouchtouris A, Nguyen XH, Goto A, Orian A, Bonnay F, Fauvarque MO, Reichhart JM, Matt N. (2020) Hyd ubiquitinates the NF-κB co-factor Akirin to activate an effective immune response in Drosophila. PLoS Pathogens 27; 16:e1008458.
Prieto-Garcia C, Hartmann O, Reissland M, Braun F, Fischer T, Walz S, Schülein-Völk C, Eilers U, Ade CP, Calzado MA, Orian A, Maric HM, Münch C, Rosenfeldt M, Eilers M, Diefenbacher ME (2020) Maintaining protein stability of ∆Np63 via SP28 is required by squamous cancer cells. EMBO Mol Med. 12:e11101.
Bitman-Lotan, E., Rincon-Arano, H., Raz, G. and Orian, A. (2019). Determination of Chromatin Accessibility in Drosophila Midgut Enterocytes by in situ 5mC Labeling. Bio-protocol 9(22): e3435.
Flint-Brodsly, N. Bitman-Lotan E, Boico O, Shafat A, Monastirioti M, Gessler M, Delidakis C, Rincon-Arano H, Orian A. (2019) The transcription factor Hey and nuclear lamins specify and maintain cell identity, e-Life pii: e44745. doi: 10.7554/eLife.44745.
Li Y, Tinoco R, Elmén L, Segota I, Xian Y, Fujita Y, Sahu A, Zarecki R, Marie K, Feng Y, Khateb A, Frederick DT, Ashkenazi SK, Kim H, Perez EG, Day CP, Segura Muñoz RS, Schmaltz R, Yooseph S, Tam MA, Zhang T, Avitan-Hersh E, Tzur L, Roizman S, Boyango I, Bar-Sela G, Orian A, Ronai ZA. Et al. (2019) Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5-/- mice. Nat Commun. 10:1492. doi: 10.1038/s41467-019-09525-y.
Yanku, Y, bitman-Lotan E, Zohar Y, urant E, Zilke N, Eilers M, and Orian A (2018) Drosophila HUWE1 ubiquitin ligase regulates endoreplication and antagonizes JNK signaling during salivary gland development Cells 7, 151; doi:10.3390/cells7100151
Bitman-Lotan E, Orian A. (2018) Chromatin, Nuclear Lamins, and maintenance of the differentiated identity. Current Opinion in System Biology 8: 1-8.
Abed M, Bitman-Lotan E, Orian A. (2018) The biology of SUMO-targeted ubiquitin ligases in Drosophila development, immunity, and cancer. J. Dev. Biol. doi:10.3390/jdb6010002
Avitan-Hersh E, Orian A (2017) Targeting the Ubiquitin-Dependent Epigenetic Landscape in Cancer. Curr Pharmacol Rep DOI 10.1007/s40495-017-0102-5.
Koltun B, Shackelford E, Bonnay F, Matt N, Reichhart JM, Orian A. Dgrn, a SUMO-targeted ubiquitin ligase, is essential for Drosophila innate immunity J. Int. Dev. Biol. (2017, in-press).
Ubiquitin Ligases: New Insights, Emerging Roles and Clinical Implications. “Paving the Notch pathway with ubiquitin ligases”. Erez N. and Orian A, Nova Science Publishers, Inc. (2017).
Diefenbacher M, Orian A. (2016) Stabilization of nuclear oncoproteins by RNF4 and the ubiquitin system in cancer. Molecular &Cellular Oncology doi: 10.1080/23723556.2016.1260671.
Thomas JJ, Abed M, Heuberger J, Novak R, Zohar Y, Beltran Lopez AP, Trausch-Azar JS, Ilgan M, Benhamou D, Dittmar G, Kopan R Birchmeier W, Schwartz AL, and Orian A. (2016) RNF4-dependent oncogene activation by protein stabilization Cell Reports 16, 3388-3400
Wang M, Sang J, Ren Y, Liu K, Liu X, Zhang J, Wang H, Wang J, Orian A, Yang J, Yi J. (2015) SENP3 regulates the global protein turnover and the Sp1 level via antagonizing SUMO2/3-targeted ubiquitination and degradation. Protein Cell. DOI 10.1007/s13238-015-0216-7
Trausch-Azar JS , Abed M, Orian A, Schwartz AL. (2014) Differential regulation of PGC-1α by isoform-specific SCFFbw7ubiquitylayion. J. Cell Physiol. doi: 10.1002/jcp.24812.
Singer R, Shimshi A, Atias O, Oron E, Segal D, Hirsch JA, Tuller T, Orian A, Chamovitz DA. (2014) Drosophila COP9 Signalosome Subunit 7 interacts with multiple genomic loci to regulate development. Nuc. Acid. Research 42: 9761-9770
Fuchs Y, Brunwasser M, Haif S, Hadad J, Shneyer B, Goldshmidt-Tran O, Korsensky L, Abed M, Zisman-Rosen S, Lilach Koren, Carmi Y, Apte R, Orian A, Bejar J, and Dina Ron. (2012) Sef is a novel inhibitor of pro-inflammatory cytokine signaling, acting by cytoplasmic sequestration of NF-κB. Dev. Cell 23: 611-623
Abed M, Bitman-Lotan E, Orian A. (2011) A fly View of a SUMO-Targeted Ubiquitn Ligase “Fly” 5: 1-5, PMID 21857164.
Barry KC, Abed M, Kenyagin D, Koltun D, Phippen TP, Delrow JJ, Orian A*, Parkhurst SM*.(2011) Degringolade a Drosophila STUbL is required for cellularization, sex determination, and early embryonic patterning. Development 138: 1759-1769. (*Corresponding authors)
Abed M, Barry KC, Kenyagin D, Koltun D, Phippen TP, Delrow JJ, Parkhurst SM, and Orian, A. The STUbL protein Degringolade is a negative regulator of Hairy-mediated Groucho dependent repression. EMBO J. 30: 1289 – 1301.
Herkert B, Dwertmann A, Herold S, Abed M, Naud JF, Finkernagel F, Harms GS, Orian A, Wanzel M, Eilers M. (2010 ) The Arf tumor suppressor protein inhibits Miz1 to suppress cell adhesion and induce apoptosis. J. Cell Biol. 88: 905-918.
Orian A, Abed M, Kenyagin-Karsenti D, Boico O. (2009) DamID: A Methylation-Based Chromatin Profiling Approach Methods Mol Biol. 567:155-169.
Cinnamon E., Helman, A., Orian, A., Jiménez G. and Paroush, Z. (2008) Multiple RTK pathways down-regulate Groucho-mediated repression in Drosophila embryogenesis Development 135: 829-37.
Orian A., Delrow, J., Rosales-Nieves, E., Mona Abed, Paroush Z., Eisenman, R. N. & Parkhurst, S. M (2007) A Myc–Groucho complex integrates EGF and Notch signalling to regulate neural stem cell fate and mitosis PNAS 104: 15771-15776.
Orian A. (2006) Chromatin profiling, DamID and the emerging landscape of gene expression Curr. Op. in Genetics and Development 16: 157-164.
Orian A. Grewal S., Knoepfler P. S., Edgar B. A., Parkhurts S. M. and Eisnman R.N (2005) Genomic Binding and Transcriptional Regulation by the Drosophila Myc and Mnt Cold Spring Harbor Symp. Quant. Biol 70: 1-10.
Grewal S. S., Li L., Orian A. and Edgar B. A., (2004) Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development. Nat. Cell. Biol. 7: 295-302.
Markus Welcker*, Orian A. *, Robert N. Eisenman, and Bruce E. Clurman (2004) Regulation of Cell Growth and c-Myc by a Nucleolar Fbw7 Isoform. Cur. Biol. 14: 1852-1857. (* equal contributors).
Bianchi-Frais D., Orian A., Delrow J., Vazquez J., Rosales-Nieves A. E, and Parkhurst S. M., (2004). Hairy-mediated transcriptional repression and cofactor recruitment in Drosophila PLoS Biology 2: 975-986.
Welcker M. *, Orian A. *, Jin, J., Harper W. J., Eisenman R. N., and Clurman B. (2004) The FbW7-box protein Regulates GSK3 Phosphorylation Dependent c-Myc Protein Degradation. PNAS USA (*equal contributors), (PNAS online: May 18, 2004, 10.1073/pnas.0402770101).
Orian A., van Steensel B, Delrow J., Bussemaker H. J., Li, L., Tomoyuki, S., Williams, E., Loo, L. M., Cowley S., Yost C, Pierce S., Edgar B. A., Parkhurst S.M., and Eisenman R.N. (2003) Genomic Binding by the Drosophila Myc, Max, Mad/Mnt Transcription Factor Network Genes & Dev. 17: 1101-1114.
Hook S., Orian A., Cowley SM., and Eisenman R.N. (2002) Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and co-purifies with deubiquitinating enzymes PNAS 99: 13425-13430.